The default behaviour of the SoftGrid Application Virtualisation 4.5 client is to not allow applications to be streamed from a file, i.e. streaming an application from a local OSD file rather than from the server. If you attempt to load from a local package, you may see an error similar to this:
The SoftGrid Client could not load Adobe Reader 8 18.104.22.168.
The operation failed because you do not have sufficient permissions to stream from a file. Please report the following error code to your System Administrator.
Error code: 450260-14901604-0000180B
The fix for this is pretty simple - change the following registry DWORD value from 0 to 1
DISCLAIMER: SoftGrid Application Virtualisation 4.5 is beta software and this configuration may change by the final release.