The default behaviour of the SoftGrid Application Virtualisation 4.5 client is to not allow applications to be streamed from a file, i.e. streaming an application from a local OSD file rather than from the server. If you attempt to load from a local package, you may see an error similar to this:

The SoftGrid Client could not load Adobe Reader 8 8.1.0.137.

The operation failed because you do not have sufficient permissions to stream from a file. Please report the following error code to your System Administrator.

Error code: 450260-14901604-0000180B

The fix for this is pretty simple - change the following registry DWORD value from 0 to 1

HKLM\SOFTWARE\Microsoft\SoftGrid\4.5\Client\Configuration\AllowIndependentFileStreaming

DISCLAIMER: SoftGrid Application Virtualisation 4.5 is beta software and this configuration may change by the final release.